G-protein coupled receptors as potential drug targets for lymphangiogenesis and lymphatic vascular diseases
Identifieur interne : 006272 ( Main/Exploration ); précédent : 006271; suivant : 006273G-protein coupled receptors as potential drug targets for lymphangiogenesis and lymphatic vascular diseases
Auteurs : William P. Dunworth [États-Unis] ; Kathleen M. Caron [États-Unis]Source :
- Arteriosclerosis, thrombosis, and vascular biology [ 1079-5642 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Endothélium lymphatique (), Endothélium lymphatique (physiologie), Humains, Lymphangiogenèse (), Lymphangiogenèse (physiologie), Lymphoedème (physiopathologie), Lymphoedème (traitement médicamenteux), Protéine apparentée au récepteur de la calcitonine, Récepteurs aux lysophospholipides (physiologie), Récepteurs couplés aux protéines G (), Récepteurs couplés aux protéines G (physiologie), Récepteurs à la calcitonine (physiologie), Souris, Souris knockout.
- MESH :
- physiologie : Endothélium lymphatique, Lymphangiogenèse, Récepteurs aux lysophospholipides, Récepteurs couplés aux protéines G, Récepteurs à la calcitonine.
- physiopathologie : Lymphoedème.
- traitement médicamenteux : Lymphoedème.
- Animaux, Endothélium lymphatique, Humains, Lymphangiogenèse, Protéine apparentée au récepteur de la calcitonine, Récepteurs couplés aux protéines G, Souris, Souris knockout.
English descriptors
- KwdEn :
- Animals, Calcitonin Receptor-Like Protein, Endothelium, Lymphatic (drug effects), Endothelium, Lymphatic (physiology), Humans, Lymphangiogenesis (drug effects), Lymphangiogenesis (physiology), Lymphedema (drug therapy), Lymphedema (physiopathology), Mice, Mice, Knockout, Receptors, Calcitonin (physiology), Receptors, G-Protein-Coupled (drug effects), Receptors, G-Protein-Coupled (physiology), Receptors, Lysophospholipid (physiology).
- MESH :
- chemical , drug effects : Receptors, G-Protein-Coupled.
- chemical , physiology : Receptors, Calcitonin, Receptors, G-Protein-Coupled, Receptors, Lysophospholipid.
- chemical : Calcitonin Receptor-Like Protein.
- drug effects : Endothelium, Lymphatic, Lymphangiogenesis.
- drug therapy : Lymphedema.
- physiology : Endothelium, Lymphatic, Lymphangiogenesis.
- physiopathology : Lymphedema.
- Animals, Humans, Mice, Mice, Knockout.
Abstract
G-protein coupled receptors (GPCRs) are widely expressed cell surface receptors that have been successfully exploited for the treatment of a variety of human diseases. Recent studies in genetically engineered mouse models have led to the identification of several GPCRs important for lymphatic vascular development and function. The adrenomedullin receptor, which consists of an oligomer between calcitonin receptor-like receptor and receptor activity modifying protein 2, is required for normal lymphatic vascular development and regulates lymphatic capillary permeability in mice. Numerous studies also suggest that lysophospholipid receptors are involved in the development of lymphatic vessels and lymphatic endothelial cell permeability. Given our current lack of pharmacological targets for the treatment of lymphatic vascular diseases like lymphedema, the continued identification and study of GPCRs in lymphatic endothelial cells may eventually lead to major breakthroughs and new pharmacological strategies for the treatment of lymphedema.
Url:
DOI: 10.1161/ATVBAHA.109.185066
PubMed: 19265032
PubMed Central: 2761011
Affiliations:
- États-Unis
- Caroline du Nord
- Chapel Hill (Caroline du Nord)
- Université de Caroline du Nord à Chapel Hill
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Le document en format XML
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Dunworth</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cell and Molecular Physiology, 111 Mason Farm Road, 247 Medical Biomolecular Research Bldg., Room 6340B, CB # 7545 The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Molecular Physiology, 111 Mason Farm Road, 247 Medical Biomolecular Research Bldg., Room 6340B, CB # 7545 The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName><placeName><settlement type="city">Chapel Hill (Caroline du Nord)</settlement><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Genetics, 111 Mason Farm Road, 247 Medical Biomolecular Research Bldg., Room 6340B, CB # 7545 The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, 111 Mason Farm Road, 247 Medical Biomolecular Research Bldg., Room 6340B, CB # 7545 The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName><placeName><settlement type="city">Chapel Hill (Caroline du Nord)</settlement><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Caron, Kathleen M" sort="Caron, Kathleen M" uniqKey="Caron K" first="Kathleen M" last="Caron">Kathleen M. 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Dunworth</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cell and Molecular Physiology, 111 Mason Farm Road, 247 Medical Biomolecular Research Bldg., Room 6340B, CB # 7545 The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Molecular Physiology, 111 Mason Farm Road, 247 Medical Biomolecular Research Bldg., Room 6340B, CB # 7545 The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName><placeName><settlement type="city">Chapel Hill (Caroline du Nord)</settlement><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Genetics, 111 Mason Farm Road, 247 Medical Biomolecular Research Bldg., Room 6340B, CB # 7545 The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, 111 Mason Farm Road, 247 Medical Biomolecular Research Bldg., Room 6340B, CB # 7545 The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName><placeName><settlement type="city">Chapel Hill (Caroline du Nord)</settlement><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Caron, Kathleen M" sort="Caron, Kathleen M" uniqKey="Caron K" first="Kathleen M" last="Caron">Kathleen M. Caron</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cell and Molecular Physiology, 111 Mason Farm Road, 247 Medical Biomolecular Research Bldg., Room 6340B, CB # 7545 The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Molecular Physiology, 111 Mason Farm Road, 247 Medical Biomolecular Research Bldg., Room 6340B, CB # 7545 The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName><placeName><settlement type="city">Chapel Hill (Caroline du Nord)</settlement><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Genetics, 111 Mason Farm Road, 247 Medical Biomolecular Research Bldg., Room 6340B, CB # 7545 The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, 111 Mason Farm Road, 247 Medical Biomolecular Research Bldg., Room 6340B, CB # 7545 The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName><placeName><settlement type="city">Chapel Hill (Caroline du Nord)</settlement><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j">Arteriosclerosis, thrombosis, and vascular biology</title><idno type="ISSN">1079-5642</idno><idno type="eISSN">1524-4636</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Calcitonin Receptor-Like Protein</term><term>Endothelium, Lymphatic (drug effects)</term><term>Endothelium, Lymphatic (physiology)</term><term>Humans</term><term>Lymphangiogenesis (drug effects)</term><term>Lymphangiogenesis (physiology)</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (physiopathology)</term><term>Mice</term><term>Mice, Knockout</term><term>Receptors, Calcitonin (physiology)</term><term>Receptors, G-Protein-Coupled (drug effects)</term><term>Receptors, G-Protein-Coupled (physiology)</term><term>Receptors, Lysophospholipid (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Endothélium lymphatique ()</term><term>Endothélium lymphatique (physiologie)</term><term>Humains</term><term>Lymphangiogenèse ()</term><term>Lymphangiogenèse (physiologie)</term><term>Lymphoedème (physiopathologie)</term><term>Lymphoedème (traitement médicamenteux)</term><term>Protéine apparentée au récepteur de la calcitonine</term><term>Récepteurs aux lysophospholipides (physiologie)</term><term>Récepteurs couplés aux protéines G ()</term><term>Récepteurs couplés aux protéines G (physiologie)</term><term>Récepteurs à la calcitonine (physiologie)</term><term>Souris</term><term>Souris knockout</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Receptors, Calcitonin</term><term>Receptors, G-Protein-Coupled</term><term>Receptors, Lysophospholipid</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Calcitonin Receptor-Like Protein</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Endothelium, Lymphatic</term><term>Lymphangiogenesis</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Endothélium lymphatique</term><term>Lymphangiogenèse</term><term>Récepteurs aux lysophospholipides</term><term>Récepteurs couplés aux protéines G</term><term>Récepteurs à la calcitonine</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Endothelium, Lymphatic</term><term>Lymphangiogenesis</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Mice</term><term>Mice, Knockout</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Endothélium lymphatique</term><term>Humains</term><term>Lymphangiogenèse</term><term>Protéine apparentée au récepteur de la calcitonine</term><term>Récepteurs couplés aux protéines G</term><term>Souris</term><term>Souris knockout</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">G-protein coupled receptors (GPCRs) are widely expressed cell surface receptors that have been successfully exploited for the treatment of a variety of human diseases. Recent studies in genetically engineered mouse models have led to the identification of several GPCRs important for lymphatic vascular development and function. The adrenomedullin receptor, which consists of an oligomer between calcitonin receptor-like receptor and receptor activity modifying protein 2, is required for normal lymphatic vascular development and regulates lymphatic capillary permeability in mice. Numerous studies also suggest that lysophospholipid receptors are involved in the development of lymphatic vessels and lymphatic endothelial cell permeability. Given our current lack of pharmacological targets for the treatment of lymphatic vascular diseases like lymphedema, the continued identification and study of GPCRs in lymphatic endothelial cells may eventually lead to major breakthroughs and new pharmacological strategies for the treatment of lymphedema.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li></region><settlement><li>Chapel Hill (Caroline du Nord)</li></settlement><orgName><li>Université de Caroline du Nord à Chapel Hill</li></orgName></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Dunworth, William P" sort="Dunworth, William P" uniqKey="Dunworth W" first="William P" last="Dunworth">William P. Dunworth</name></region><name sortKey="Caron, Kathleen M" sort="Caron, Kathleen M" uniqKey="Caron K" first="Kathleen M" last="Caron">Kathleen M. Caron</name><name sortKey="Caron, Kathleen M" sort="Caron, Kathleen M" uniqKey="Caron K" first="Kathleen M" last="Caron">Kathleen M. Caron</name><name sortKey="Dunworth, William P" sort="Dunworth, William P" uniqKey="Dunworth W" first="William P" last="Dunworth">William P. Dunworth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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